Frances Harriett Greville married Charles Gordon-Lennox, 6th Duke of Richmond and Gordon, in 1843. The couple had four sons and two daughters.

According to her obituary she was "especially beloved for her kind-hearted interest in the poorer classes and her ever-present desire to promote and engage in good works for their benefit."

The Duchess was highly regarded in Fochabers as she had instructed that the estate workers should be provided with better housing. Thatched roofs were replaced with slate roofs, giving local tradesmen several years of employment. These houses became known as 'the Duchess' Houses'. The Duke had water piped in from the Fochabers burn and the Duchess had a bathhouse with six cubicles built in Castle Street. Cold baths cost 1d and hot baths 2d. They put water cisterns in the houses and had the sewage redirected from the Fochabers burn to the river Spey. The Duchess also bought books and set up a library in Fochabers in the mid 1870s.

She was buried in Chichester Cathedral.